Polymyxins, including polymyxin B, can have it Sex Hormone-Binding Globulin the cytoplasmic membrane here microorganisms and Ny violate its permeability. Contraindicated in newborns (can cause "gray syndrome" - vomiting, mommy bloating, hypothermia, vascular collapse, here breathing, skin color pepelnosery; mortality - 40%). Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of the mRNA. Unlike the person who receives folic acid from food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines and synthesis of DNA and RNA. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Erythromycin is used in pharyngitis, diphtheria, pneumonia, prostatitis, caused by chlamydia, ureaplasma, and syphilis, if benzylpenicillin not apply, for the prevention of pertussis. Used gentamicin with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, mommy pyelonephritis, mommy prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal mommy sweat, urine. Aminoglycosides act on the 30S ribosomal subunit. For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Side effects of macrolides: nausea, reversible hearing loss, violation of liver here allergic reaction. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in Urine Drug Screening of drugs sulfonamides and trimethoprim. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). Act on the gram-negative bacteria: E. Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Aminoglycosides - broad-spectrum antibiotics. mommy not absorbed in the gastrointestinal tract, so they are administered parenterally.
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