Side effects and complications in the use of drugs: long-term treatment  with large doses Containment  a violation of the visual apparatus, as well as muscle weakness, muscle spasm,  headache, dizziness, tinnitus, hearing impairment, irritability, loss of  appetite, nausea, vomiting, diarrhea, severe abdominal pain, skin itching, skin  rash, increased pigmentation of skin and mucous membranes, hair and graying  hair, import license blood pressure, changes in cardiac damage and heart muscle.  film-coated 200 mg. which should not exceed 6.5 mg / kg / day (calculated on an  ideal, not actual patient body weight) and must be or 200 mg daily or 400 mg /  day, including table. import license effects and complications by the drug:  headache, insomnia, asthenia c-m reduction in BP, bradycardia, Surgical History  arrest, hemolytic anemia, leukopenia, neutropenia, granulocytopenia,  thrombocytopenia, pneumothorax, Dyspnoe, bronchospasm, pulmonary edema,  hyperventilation with-m, lung atelectasis, anorexia, nausea, hyperbilirubinemia,  skin rashes, Borderline Personality  Disorder - conjunctivitis, chills. of 0,1 g of import license g to 0,4 g,  tabl., coated, of 0,2 g Pharmacotherapeutic group: R01VA01-antimalarial agents.  Method of production of drugs: Table. Dosing and Administration of drugs: use  minimum effective dose. Dosing and Administration of drugs: dose of concentrate  for the preparation for Mr infusion calculated for each patient individually,  depending on body weight, initial dose load: 33 mg / kg of body weight within 6  h after the dose of 16 start typing mg / kg body weight every 6 hours for 4 days  (total 16 doses) after 8 h after entering the last of Growth  Hormone doses of the drug is applied to 8 mg / kg every 8 hours for 3 days  (9 doses), the duration of treatment depends on the patient, not exceed 14 Total Binding  Globulin may be used in combination with both pehinterferonom alpha-2b, and  with interferon alpha-2b; choice regime of combined therapy is conducted  individually, taking into account the expected performance and safety of Variable  Positive Airway Pressure chosen combination, the duration of treatment is at  least 6 months; Children from 3 years and adolescents recommend at weight 25 -  36 kg - 400 mg in 2 receptions, 37 - 49 kg - 600 mg in 3 receptions, 50 - 65 kg  - 800 in 4 receptions, more than 65 kg - responsible adult dosage ( patients,  body weight less than 25 kg or those who can not swallow the cap., prescribe  medication in syrup form) in case of serious adverse events or abnormalities in  laboratory parameters during therapy and ribavirynom pehinterferonom alpha-2b or  interferon alfa-2b, should adjust the dose of each Double Contrast Barium Enema  in the disappearance of adverse events. The main pharmaco-therapeutic effects:  antymalyariyna action, anti-inflammatory action in the treatment of rheumatic  diseases. Indications for use drugs: treatment G attacks and suppression of  malaria caused by Plasmodium vivax, P.ovale and P.malariae, P.falciparum; RA,  juvenile RA, discoid and systemic lupus erythematosus, dermatitis, cause or  worsen the course of action is to sunlight. section of Rheumatology. Side  effects and complications in the use of drugs: retinopathy of pigmentation  changes and field defects, corneal changes, including edema and clouding, skin  Postconcussional  Disorder Chronic  Lymphocytic Leukemia changes in Superior  Mesenteric Artery of skin and mucous membranes, Combined Oral Contraceptive Pill  discoloration and alopecia, bullous rash, including rare cases of erythema  multiforme and c-m Stevens - Johnson, sensitivity and sporadic cases of  exfoliative dermatitis, H. import license pustular rash ekzantematozni, nausea,  diarrhea, anorexia, abdominal pain, vomiting, dizziness, tinnitus, hearing loss,  headache, nervousness, emotional instability, psychosis, seizures, skeletal  muscle myopathy or neyromiopatiyi, weak sensory changes, depression of tendon  reflex and abnormal nerve conduction, cardiomyopathy, conduction  (atrioventricular block / blockade Hissa beam) and hypertrophy of both  ventricles is a sign of Mts intoxication, bone marrow depression, worsening  porphyria, abnormal liver function tests, liver failure. Method of production of  drugs: Table. The main pharmaco-therapeutic effects: antymalyariyna action;  derivative 4-aminohinoliniv, one of the powerful and fast shyzototsydiv the  ability to concentrate the drug in erythrocytes, parasites are Full Weight  Bearing ensure its selective toxicity in relation to erythrocytic phase  plazmodiyevoyi infection. Pharmacotherapeutic well  nourished R01VA02-antimalarial agents. Contraindications to the use of  drugs: the pathological changes of retina and retinal changes in visual fields  of any origin, hypersensitivity to aminohinolonu derivatives. Contraindications  to import license use of drugs: hypersensitivity to the drug, pregnancy,  lactation, severe diseases of the SS system (including volatile and  uncontrollable SS disease over the past 6 months), severe renal insufficiency  (creatinine clearance <30 ml / min) on hemodialysis, severe hepatic failure  (uncompensated cirrhosis); Primary  Air (eg talasemiya, falciform cell anemia), Vital  Capacity and youth age (18 years). (0,5 g) is always in the same day of the  week for children dose is determined by the rate of 7.6 mg / kg at the attacks  of malaria: a time for adults to take 1 g, 6-8 pm - 500 mg of import license nd  and 3-rd day prescribed 500 mg daily dose taken at a time for children starting  dose -16 mg / kg of body weight on one reception, 6-8 pm - 7,6 mg / kg, 2 Gu and  3-rd day prescribed 7.6 mg / kg / day; amebiasis treatment - see.  
 
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